The relationships of The Grand Inquisitor.
- Main article: Darth Vader
The Grand Inquisitor answered only to Darth Vader, his master, regarding news of his exploits across the galaxy.
When he is defeated by Kanan in Fire Across the Galaxy, the Grand Inquisitor warns the Jedi he has no idea what he has unleashed, and that there are some things more frighting than death, before he allows himself to fall to his own. His taking own life and last words imply the Inquisitor feared whatever punishment Vader would have for him; he was obviously more afraid of his master's wrath than death itself.
- Main article: Kallus
The Grand Inquisitor and Kallus worked very closely together, as they shared the same aim: to eliminate the remaining Jedi. Kallus later came to the belief that the Inquisitor was focusing too much on capturing the two Jedi then the rebels as a whole, and came to the conclusion that "if we catch my rebels, we catch his Jedi". It is unknown what the Inquisitor's reaction to this was.
- Main article: Ezra Bridger
The Grand Inquisitor had an interest (albeit a passing one) in Ezra that appeared to become a desire to make Ezra his apprentice despite being enemies. The Inquisitor tried to sway Ezra to turn to the Dark Side, and threatened to destroy all that the boy cares about, which provoked Ezra into briefly giving into the Dark Side. The Inquisitor seemed to respect Ezra as a worthy opponent. However when Ezra was fighting the Inquisitor with Kanan in a Star Destroyer's reactor core, he had no problem pushing Ezra off the ledge to his supposed death.
- Main article: Kanan Jarrus
Kanan, as well as Ezra, was the Grand Inquisitor's main objective, in his task as a Jedi hunter. When first they met the Inquisitor was unimpressed with Kanan's lightsaber skills and correctly deduced his master to have been Depa Bilaba. He saw him as prey and obstacle, but the more they clashed the more he found Kanan to be a better Jedi up until the Inquisitor captured him. During the time the Inquisitor tortured Kanan, he sadistically taunted him for running as his master gave her life to protect him. In their final duel, when Kanan found his resolve, both the Inquisitor and the Jedi gave each other a salute of respect and the Inquisitor was shocked to be bested though he warned his conqueror what the Jedi's actions had unleashed before taking his own life.
Despite them being mortal enemies, Kanan was visibly shocked by the Inquisitor's deliberate suicide and in fact unconsciously regretted not having attempted to save him.